curcumin-loaded chitosan tripolyphosphate nanoparticles as a safe, natural and effective antibiotic inhibits the infection of staphylococcus aureus and pseudomonas aeruginosa in vivo

نویسندگان

reza mirnejad

mirza ali mofazzal jahromi

sharafaldin al-musawi

majid pirestani

mahdi fasihi ramandi

چکیده

background: curcumin as a yellow natural compound extracted from turmeric root is known it as an antibacterial agent. one of the nanoparticles ability is to decrease the defects of usual drug delivery systems. chitosan is a low toxic, biodegradable, biocompatible and safe polymer which is used in production of nanoparticles. nanoparticles like chitosan-tripolyphosphate (tpp) are able to increase antibacterial properties of curcumin. materials and methods: curcumin-loaded chitosan-tpp nanoparticles containing chitosan, curcumin and tpp salt were synthesized by ionotropic gelation methods. first, the skin of anesthetized mice was inoculated with staphylococcus aureus and pseudomonas aeruginosa suspension. then the infected mice were treated with curcumin-loaded chitosan-tpp nanoparticles for 3 days. following that, antibacterial characteristics of the mice treated with curcumin-loaded chitosan-tpp nanoparticles were evaluated by bacterial culture of these mice. results: our results showed the size of 160±10 nm and the charge of +7 ± 2 mv in curcumin-loaded chitosan-tpp nanoparticles. these nanoparticles were also spiral shape. the encapsulating efficiency of curcumin in chitosan-tpp nanoparticles was 75 ± 2%. bacterial culture showed that curcumin-loaded chitosan-tpp nanoparticles inhibited staphylococcus aureus and pseudomonas aeruginosa growth. conclusion: our study demonstrated that curcumin-loaded chitosan-tpp nanoparticles can be utilized as a potent agent in treatment of staphylococcus aureus and pseudomonas aeruginosa infections.

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Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe, natural and effective antibiotic inhibits the infection of Staphylococcus aureus and Pseudomonas aeruginosa in vivo

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عنوان ژورنال:
iranian journal of biotechnology

ناشر: national institute of genetic engineering and biotechnology

ISSN 1728-3043

دوره 12

شماره 3 2014

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